Cytotoxic Effects of Salvia officinalis Extraction MCF-7 Human Breast Cancer Cells
DOI:
https://doi.org/10.63912/kjaise.v1i0.0005Keywords:
MCF-7, Breast cancer, Salvia officinallis, CytotoxicityAbstract
Salvia officinalis (sage) is a medicinal plant known for its antioxidant and potential anticancer properties. This study aimed to evaluate the cytotoxic effects of sage extract on human breast cancer cells (MCF-7). MCF-7cells were treated with varying concentrations of sage extract ,and cell viability was assessed using the MTT assay. Results demonstrated a dose-dependent reduction in cell viability, with the highest extract concentration reducing viability by approximately 60%. The estimated IC₅₀ value indicated moderate cytotoxic potency. These findings suggest that Salvia officinalis contains bioactive compounds capable of inhibiting breast cancer cell proliferation. Further studies are recommended to elucidate the underlying mechanisms and evaluate its therapeutic potential in-vivo.
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